Ecology 22 - BIOLOGY JUNCTION

Molecular Genetics: Problem 1A man with hemophilia (a recessive , sex-linked condition has a daughter of normal phenotype. She marries a man who is normal for the trait. What is the probability that a daughter of this mating will be a hemophiliac? A son? If the couple has four sons, what is the probability that all four will be born with hemophilia?

Genotypes:

A man with hemophilia is XhY where h = hemophilia gene and H = the normal gene.
Any daughter with normal phenotype whose father has hemophilia will be a carrier.

Her genotype must be:

XhXH and NOT XHXH We can use a Punnett square to show the probability of a daughter or son having hemophilia.

daughter x normal manXhXH x XHY

A. If the daughter marries a normal male the probability of a daughter having hemophilia is zero.

B. About 50% of male children would have hemophilia (Boxes 2 and 4 above)

C. The probability that all 4 sons have inherited hemophilia would be: 1/2 x 1/2 x 1/2 x 1/2 or 1/16.

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Genetic Disorders to Present

Internet resources to help in research

Rubric for project

You have been challenged to incorporate your knowledge about cells, cell division, genetics, and DNA to research and present on a specific genetic disorder. You have already completed your basic study about the ideas of genetics and mutations. Now with the information that you have you are being asked to research a specific genetic disorder and give an oral presentation along with creating either a PowerPoint or poster to explain the genetic disorder.

Your multimedia presentation (powerpoint / poster) along with your oral presentation
should include the following points.

What is the name of the disorder and what is the history behind the disorder? Who discovered it or/and who have done research on the disease?
How is the disorder diagnosed? How does a person receive the disorder? Is it sex-linked? Is it a mutation? Is it due to heredity?
You will need to find out all of the signs and symptoms of the given disorder and share these with the class.
What types of treatment there are for the disorder?
Include a suggested list of readings and/or Internet sources that may be of interest to the class.
You are encouraged to share any other information that you feel is relevant that you feel is important for others to know about the genetic disorder.

List of possible Genetic Disorders to Present:
Achondroplasia (Dwarfism) Albinism Adrenal hyperplasia Autism/ Asperger syndrome Cystic Fibrosis Down Syndrome (Trisomy 21) Duchenne Muscular Dystrophy Familial Dysautonomia Gardner syndrome (intestinal polyposis) Gaucher’s Disease Hemophilia Huntington’s Disease Jacobsen Syndrome Klinefelters Syndrome Klippel-Feil Syndrome	Leukodystrophy Lou Gehrig’s Disease (ALS) Marfan Syndrome Moebius Syndrome Polycystic Kidney Disease Progeria Proteus Syndrome Retinoblastoma Rett’s Syndrome Spinocerebellar Ataxia Tay-Sachs Disease Tourette Syndrome Turner Syndrome

List of internet resources that may be helpful to you in creating your presentation:

Yahoo – Genetic Disorders http://dir.yahoo.com/Health/Diseases_and_Conditions/Genetic_Disorders/.
Site explains several different disorders and contains links to all of the different types of genetic disorders.

Genetic & Rare Conditions Sitehttp://www.kumc.edu/gec/support/.
links to different types of disorders in alphabetical order.

What can our chromosomes tell us? http://biology.about.com/science/biology/gi/dynamic/offsite.htm?site=http://gslc.genetics.utah.edu/.
A site that talks about karyotyping of genotypes.

Genetic Disorder Library
http://learn.genetics.utah.edu/units/disorders/whataregd
To learn more about different genetic disorders, browse through the Genetic Disorder Library.

A Genetics Glossary http://biology.about.com/science/biology/gi/dynamic/offsite.htm?site=http://helios.bto.ed.ac.uk/bto/glossary/index.html
A basic genetic glossary.

Genetics Education Center http://www.kumc.edu/gec/.
Seeks to help educate people about genetics.

The National Human Genome Research Institute http://www.nhgri.nih.gov/.
Explains about the human genome project.

Department of Energy – Human Genome Project Information http://www.ornl.gov/hgmis/.
Provides a lot of information about the human genome project.

A Gene Map of the Human Genome http://www.ncbi.nlm.nih.gov/science96/.
You can see the mapping of several different chromosomes found within the body.

Learning about the Human Genome Project and Genetics through the World Wide Web http://www.kumc.edu/gec/hgpwww.html.
Looks at the ethical issues of genetic research.

Understanding Gene Testinghttp://www.accessexcellence.org/ae/AE/AEPC/NIH/index.html.
This site talks of how genes are linked to disease and how a gene creates a genetic disorder.

Basics of DNA Fingerprintinghttp://www.biology.washington.edu/fingerprint/dnaintro.html.
Explains the basic understanding of DNA fingerprinting.

What is Genetic Testing? http://www.lbl.gov/Education/ELSI/Frames/genetic-testing-f.html.
Shows the basics of genetic testing and talks about the ethical issues of that happen due to genetic testing.

Rubric for Evaluation of Genetic Disorder Presentation.

Beginning 5 points	Developing 10 Points	Accomplished 15 Points	Exemplary 20 Points	Total Score
Oral Presentation Quality of Information	Bare minimums have been accomplished. Little understanding about the genetic disorder delivered in oral presentation. Could only read slides with no further understanding.	Minimums plus slight extras added. Answered questions from the intro and at least one question posed to them in the process section.	All information present and complete. Some problems with flow and delivery. Shows more or less some understanding of knowledge – has minor flaws.	Information is well thought out, flows well, all information is completed, Appears to have been practiced, knowledge shown.
Bibliography Amount of additional Information for reading and websites found and presented	no additional reading lists or websites provided or presented in bibliography.	At least 2 web sites or books accessed and verified in presentation and presented in bibliography.	At least 4 web sites or books accessed and verified in presentation and presented in bibliography.	At least 6 web sites or books accessed and verified in presentation and presented in bibliography.
Organization of presentation	Random information is presented	Disorganized at times.	Organized	Organized effectively with easy understanding.
Use of class time working on project	Majority of class time was wasted.	Half of class time was wasted.	Little class time was wasted.	No class time was wasted.
Overall Multimedia Presentation	Disorganized Not Completed Missing Key Component Questions no graphics.	Spelling errors present presentation has some flow to it but is choppy.	Easily understood by all. Includes graphics and data tables of information retrieved.	Neatly done, organized, proper spelling, allparts included,above and beyond effort. Information that is presented is aesthetically pleasing to the eye.
Link to printable rubric in word document format Link to Bibliography Citation Machine				TOTAL SCORE

Category: Ecology

Campbell Chapter 14 Gen Prob 1

Genetic Disorder Project Presentation